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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Sulforaphane, Temozolomide
Phytochemical Name Sulforaphane (PubChem CID: 5350 )
Anticancer drug Name Temozolomide (PubChem CID: 5394 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Reversing Drug Resistance
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Combination Pair ID: 552
Ref_1
Pair Name Sulforaphane, Temozolomide
Disease Info [ICD-11: 2A00] Glioblastoma multiforme Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression CASP3 hsa836
Down-regulation Expression MGMT hsa4255
Down-regulation Expression MKI67 hsa4288
Down-regulation Expression MMP2 hsa4313
Down-regulation Expression MMP9 hsa4318
Down-regulation Expression RELA hsa5970
In Vitro Model U-87MG ATCC Glioblastoma Homo sapiens (Human) CVCL_0022
U-373MG ATCC Astrocytoma Homo sapiens (Human) CVCL_2219
In Vivo Model Nude mouse models were established with U373-R GBM cells inoculated subcutaneously into the right flanks of 4–6-week-old female mice.
Result The present study suggests that the clinical efficacy of TMZ-based chemotherapy in TMZ-resistant GBM may be improved by combination with SFN.
03. Reference
No. Title Href
1 Sulforaphane reverses chemo-resistance to temozolomide in glioblastoma cells by NF-κB-dependent pathway downregulating MGMT expression. Int J Oncol. 2016 Feb;48(2):559-68. doi: 10.3892/ijo.2015.3271. Click
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